Discovery of Novel c-Met Inhibitors Bearing a 3-Carboxyl Piperidin-2-one Scaffold
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چکیده
منابع مشابه
Discovery of novel c-Met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold.
A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indicated that five compounds exhibited significant inhibitory effect on c-Met with IC50 values of 8.6-81 nM and four compounds showed potent inhi...
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In the title mol-ecule, C(15)H(17)NO(3), the piperidine ring adopts a chair conformation. The dihedral angle between the two furyl rings is 72.4 (1)°. The ethyl group and the furyl rings have equatorial orientations. Mol-ecules are linked by N-H⋯O hydrogen bonds.
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ژورنال
عنوان ژورنال: Molecules
سال: 2014
ISSN: 1420-3049
DOI: 10.3390/molecules19022655